Genetic polymorphism of platelet glycoprotein Ib

molecular weight polymorphism of glycoprotein Ib alpha Human platelet

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Platelet Glycoprotein Ib-IX and Malignancy

Human platelet-specific antigen, Siba, is associated with the molecular weight polymorphism of glycoprotein Ib alpha.

Platelet-specific antigen Sib(a) has been highly implicated in the pathogenesis of refractoriness to human leukocyte antigen (HLA)-matched platelet transfusions in Japan. We provide evidence that the Sib(a) antigen is located on the glycoprotein (GP) Ib alpha and has a close association with the molecular weight (mol wt) polymorphism of GPIb. In modified antigen-capture ELISA (MACE), anti-Sib(a...

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.

OBJECTIVE The platelet glycoprotein Ib-IX (GP Ib-IX) receptor is a well-characterized adhesion receptor supporting hemostasis and thrombosis via interactions with von Willebrand factor. We examine the GP Ib-IX/von Willebrand factor axis in murine polymicrobial sepsis, as modeled by cecal ligation and puncture (CLP). APPROACH AND RESULTS Genetic absence of the GP Ib-IX ligand, von Willebrand f...

A short history of platelet glycoprotein Ib complex.

At that time it was not clear that a platelet receptor was deficient, and the first clues in that direction came from studies towards the end of 1960s showing first that Bernard-Soulier platelets had less negative charge than normal platelets and this was due to decreased amounts of sialic acid (5). Studies on the major ligand for GPIb, von Willebrand factor (vWF), and its interactions with pla...